Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514788 | PMC |
| http://dx.doi.org/10.1128/AAC.48.9.3556-3558.2004 | DOI Listing |
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