[A new procedure in making reliable experimental models of gastroesophageal reflux].

Objective: To provide a reliable experimental model for gastroesophageal reflux (GER) study.

Methods: Twenty Japan 5-month-old male rabbits were randomly divided into two groups: group cardiomyotomy (n=10), group partial cardiomyectomy (n=10). The operations of cardiomyotomy and parital cardiomyectomy were performed in 2 groups respectively. All the animals underwent intraesophageal pH detection 1 week before operation and 4 weeks after operation. The mean changes of reflux ratios were compared between before operation and after operation.

Results: In gastroesophageal reflux ratio between before operation and after operation, there was no significant difference in group cardiomyotomy (1.98%+/-1.52% and 4.32%+/-2.39%, P>0.05) and there was significant difference in group partial cardiomyectomy (1.56%+/-1.57% and 13.56%+/-3.27%, P<0.05).

Conclusion: The reliable experimental model of GER can be made with procedure of partial cardiomyectomy. It can be used in estimating the operative procedure of anti-reflux and is conducive to dynamic observation and study of esophagitis.