Salivary duct carcinoma (SDC) is an uncommon, high-grade tumor. We present 8 cases of sarcomatoid SDC, which has been defined recently as a rare variant of SDC. The 8 patients (5 men, 3 women) had a mean age of 63.6 years. Histologically, all tumors were characterized by a biphasic neoplasm composed of both SDC and sarcomatoid elements. In 3 cases, sarcomatoid components showed osteosarcomatous heterologous differentiation. A residual pleomorphic adenoma was detected in 5 tumors. The sarcomatoid component showed focal immunoreactivity for cytokeratin in 4 cases and epithelial membrane antigen in all 8 cases. Diffuse p53 immunostaining was detected in 3 cases, and it was coexpressed in both components. Our observations support the histogenetic theory of a common origin of the carcinomatous and sarcomatoid populations. Of the 13 patients, including our 8, reported to have sarcomatoid SDC arising in a major salivary gland and for whom long-term follow-up data were available, 7 have died of disease (mean survival, 15.6 months). These results indicate that sarcomatoid SDC is a highly aggressive tumor, similar to conventional SDC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1309/5J40-08QR-Y1HW-W5W4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Salivary duct carcinoma with squamous differentiation: histomorphological and immunophenotypical analysis of six cases.
Histopathology
October 2024
Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Background And Aims: Salivary duct carcinoma (SDC) is an aggressive salivary malignancy with multiple morphological subtypes. Primary salivary squamous cell carcinoma (SCC) requires exclusion of high-grade salivary malignancies and metastatic disease and is considered exceptionally rare. We report six cases of SDC with resemblance to SCC on account of variable, but often extensive, squamous differentiation.
View Article and Find Full Text PDFGenomic alteration in rare subtype of sarcomatoid salivary duct carcinoma.
Pathol Res Pract
December 2021
Departments of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. Electronic address:
Article Synopsis
- Salivary duct carcinoma (SDC) is a dangerous type of salivary gland cancer with a variety of forms, including a rare variant called sarcomatoid SDC, which was the focus of this study.
- The research examined three patients with sarcomatoid SDC, analyzing their cancer characteristics and molecular profiles, revealing that the tumors had both invasive ductal carcinoma and sarcomatoid features.
- Key findings included that diagnostic markers like androgen receptor (AR) and epithelial membrane antigen (EMA) were consistent across different tumor areas, and that genetic changes in the sarcomatoid variant were similar to those in the typical variant of SDC, suggesting a shared pathology.
Salivary duct carcinoma with rhabdoid features: a salivary counterpart of pleomorphic lobular carcinoma of the breast.
Histopathology
January 2017
Pathology Division, Shizuoka Cancer Centre, Sunto, Shizuoka, Japan.
Aim: To analyse the clinicopathological features and immunohistochemical characteristics of nine cases of salivary duct carcinoma (SDC) with rhabdoid features (SDCRF), representing a new, extremely rare type of salivary gland malignancy.
Methods And Results: We analysed 2511 cases of salivary gland tumour, clinicopathologically and immunohistochemically. The incidence of SDCRF was 0.
Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.
Sci Rep
August 2015
Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Salivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS A146T and Q61H mutations in 2 out of 4 (50%) sarcomatoid SDC variants. Transgenic mice carrying the human oncogenic KRAS(G12V), which spatiotemporal activation by tamoxifen (TAM)-inducible Cre recombinase Ela-CreERT in the submandibular gland (SMG) ductal cells, was established and characterized.
View Article and Find Full Text PDFSalivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression.
Am J Surg Pathol
May 2015
*University of Pittsburgh Medical Center, Pittsburgh ∥Department of Pathology, Thomas Jefferson University, Philadelphia, PA †Southern California Permanente Medical Group, Woodland Hills, CA §Virginia Mason Medical Center, Seattle, WA ‡University Health Network, Toronto #Department of Pathology, University of Ottawa, Ottawa, ON, Canada ¶Aga Khan University Hospital, Karachi, Pakistan.
Salivary duct carcinoma (SDC) is a prototypic aggressive salivary gland carcinoma. Our aim is to determine the prevalence of histologic variants (micropapillary, basal-like) and androgen receptor (AR) expression in a large multi-institutional series of SDC. AR status was determined by immunohistochemistry (IHC).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!