HIV/AIDS: impact on maternal mortality at the Johannesburg Hospital, South Africa, 1995-2001.

This study investigated maternal mortality at the Johannesburg Hospital, a 1100-bed academic hospital in South Africa. Patient records were assessed retrospectively over two time periods: 1995/1996 and 2000/2001. Causes of death were noted and compared with national data. The two time periods were compared to identify disease patterns and the role of anaesthesia in maternal mortality. The maternal mortality ratios were respectively 183 and 354 per 100000 live births respectively. Hypertension in pregnancy was the leading cause of mortality in 1995/1996, accounting for 10 out of the 20 deaths, but was the second most common cause in 2000/2001 (6 out of 35). HIV/AIDS-associated disease was the leading cause of mortality in 2000/2001 (42.7%, increasing from 20% in 1995/1996) with pneumonia the commonest cause of death. The statistics at this hospital were consistent with the national trend of an increasing association with HIV/AIDS. No deaths were found to be directly attributable to anaesthesia in either of the time periods. There is a need for clearer documentation of HIV status in pregnancy and antiretroviral intervention strategies must be considered.