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Effects of periodontal disease on the proteomic profile of the periodontal ligament.
J Proteomics
January 2025
Department of Diagnosis and Surgery, School of Dentistry at Araraquara, São Paulo State University - UNESP, Araraquara, São Paulo, Brazil; Department of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Periodontal disease affects over 1 billion people globally. This study investigated how periodontitis affects the protein profile of the periodontal ligament (PDL) in rats. Eight Holtzman rats were divided into the control and experimental periodontitis groups.
View Article and Find Full Text PDFThe molecular mechanism of temperature-dependent phase separation of heat shock factor 1.
Nat Chem Biol
January 2025
MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Heat shock factor 1 (HSF1) is the critical orchestrator of cell responses to heat shock, and its dysfunction is linked to various diseases. HSF1 undergoes phase separation upon heat shock, and its activity is regulated by post-translational modifications (PTMs). The molecular details underlying HSF1 phase separation, temperature sensing and PTM regulation remain poorly understood.
View Article and Find Full Text PDFPushing the boundaries: future directions in the management of spinal muscular atrophy.
Trends Mol Med
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MDUK Oxford Neuromuscular Centre, Department of Paediatrics, University of Oxford, Oxford, OX3 9DU, UK; NIHR Oxford Biomedical Research Centre, Oxford, OX3 9DU, UK; Neuromuscular Centre, Division of Paediatrics, University Hospital of Liège and University of Liège, 4000, Liège, Belgium. Electronic address:
Spinal muscular atrophy (SMA) is a devastating, degenerative, paediatric neuromuscular disease which until recently was untreatable. Discovery of the responsible gene 30 years ago heralded a new age of pioneering therapeutic developments. Three disease-modifying therapies (DMTs) have received regulatory approval and have transformed the disease, reducing disability and prolonging patient survival.
View Article and Find Full Text PDFGut Microbiota and Diabetes: Pioneering New Treatment Frontiers.
Endocr Metab Immune Disord Drug Targets
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Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Lovely Professional University, Panjab, 144001, India.
Diabetes Mellitus (DM) is a complex metabolic disorder characterized by chronic hyperglycemia and poses significant global health challenges. Conventional treatments, such as insulin therapy and lifestyle modifications, have shown limited efficacy in addressing the multifactorial nature of DM. Emerging evidence suggests that gut microbiota, a diverse community of microorganisms critical for metabolism and immune function, plays a pivotal role in metabolic health.
View Article and Find Full Text PDFModelling mixed crop-livestock systems and climate impact assessment in sub-Saharan Africa.
Sci Rep
January 2025
Institute of Crop Science and Resource Conservation, University of Bonn, Katzenburgweg 5, D-53115, Bonn, Germany.
Climate change significantly challenges smallholder mixed crop-livestock (MCL) systems in sub-Saharan Africa (SSA), affecting food and feed production. This study enhances the SIMPLACE modeling framework by incorporating crop-vegetation-livestock models, which contribute to the development of sustainable agricultural practices in response to climate change. Applying such a framework in a domain in West Africa (786,500 km) allowed us to estimate the changes in crop (Maize, Millet, and Sorghum) yield, grass biomass, livestock numbers, and greenhouse gas emission in response to future climate scenarios.
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