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Impact of SCN10A Polymorphism on Abdominal Pain Perception and Visceral Hypoalgesia in Crohn's Disease and Ulcerative Colitis.
Clin Transl Gastroenterol
December 2024
Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Introduction: Hypoalgesic inflammatory bowel disease (IBD) may provide critical insights into human abdominal pain. This condition was previously associated with homozygosity for a polymorphism (rs6795970, A1073V; 1073 val/val ) related to Na v 1.8, a voltage-gated sodium channel preferentially expressed on nociceptors.
View Article and Find Full Text PDFf. sp. Exhibited a Significant Change in Virulence and Race Frequency in Xinjiang, China.
J Fungi (Basel)
December 2024
Institute of Plant Protection, Xinjiang Academy of Agricultural Sciences/Key Laboratory of Integrated Pest Management on Crop in Northwestern Oasis, Ministry of Agriculture and Rural Affairs, Urumqi 830000, China.
Xinjiang is an important region due to its unique epidemic characteristics of wheat stripe rust disease caused by f. sp. .
View Article and Find Full Text PDFRegulation Roles of Juvenile Hormone Epoxide Hydrolase Gene 2 in the Female River Prawn Reproductive Process.
Curr Issues Mol Biol
November 2024
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
In this study, we investigated the regulatory roles of the () gene in the reproductive process of female . Its total cDNA length was 1848 bp, encoding for 460 amino acids. It contained conserved domains typical of epoxide hydrolases, such as the Abhydrolase family domain, the EHN epoxide hydrolase superfamily domain, and the "WWG" and "HGWP" motifs.
View Article and Find Full Text PDFThe Use of Gel Electrophoresis to Separate Multiplex Polymerase Chain Reaction Amplicons Allows for the Easy Identification and Assessment of the Spread of Toxigenic Strains.
Gels
December 2024
Microbiology Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 Maria Skłodowska-Curie Street, 85-094 Bydgoszcz, Poland.
is a common etiological factor of hospital infections, which, in extreme cases, can lead to the death of patients. Most strains belonging to this bacterium species synthesize very dangerous toxins: toxin A (TcdA) and B (TcdB) and binary toxin (CDT). The aim of this study was to assess the suitability of agarose gel electrophoresis separation of multiplex PCR amplicons to investigate the toxinogenic potential of strains.
View Article and Find Full Text PDFHotspots and status of Fetal Alpha-Thalassemia from 2009 to 2023: a bibliometric analysis.
Front Pediatr
December 2024
Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, China.
Objective: to evaluate the research status and development hotspots of fetal α-thalassemia by quantitatively analyzing the diagnostic status, key areas, related management measures and prospects of the disease by bibliometrics.
Methods: The global literature on fetal α-thalassemia and severe α-thalassemia from 2009-2023 in the Web of Science Core Collection (WOSCC) was visually analyzed by VOSviewer and CiteSpace.
Results: (1) The examination of the quantity of publications concerning fetal α-thalassemia indicates a rising tendency prior to 2018, followed by a decrease after 2018.
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