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Analyzing aptamer structure and interactions: in silico modelling and instrumental methods.
Biophys Rev
December 2024
Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.
Aptamers are short oligonucleotides that bind specifically to various ligands and are characterized by their low immunogenicity, thermostability, and ease of labeling. Many biomedical applications of aptamers as biosensors and drug delivery agents are currently being actively researched. Selective affinity selection with exponential ligand enrichment (SELEX) allows to discover aptamers for a specific target, but it only provides information about the sequence of aptamers; hence other approaches are used for determining aptamer structure, aptamer-ligand interactions and the mechanism of action.
View Article and Find Full Text PDFStructural and Dynamic Heterogeneity of Deep Eutectic Solvents Composed of Choline Chloride and Ortho-Phenol Derivatives.
J Phys Chem B
January 2025
Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Structural, thermal, and dynamic properties of four deep eutectic solvents comprising choline chloride paired with phenolic derivative hydrogen-bond donors were probed using experiments and molecular simulations. The hydrogen-bond donors include phenol, catechol, -chlorophenol, and o-cresol, in a 3:1 mixture with the hydrogen-bond acceptor choline chloride. Density, viscosity, and pulsed-field gradient NMR diffusivity measurements were conducted over a range of temperatures.
View Article and Find Full Text PDFLiAlClS: a low-cost and high-performance solid electrolyte for solid-state batteries.
Chem Sci
January 2025
Materials Science and Engineering Program, The Graduate School, Florida State University 2005 Levy Ave. Tallahassee FL 32310 USA
Solid electrolytes (SEs) are crucial for advancing next-generation rechargeable battery technologies, but their commercial viability is partially limited by expensive precursors, unscalable synthesis, or low ionic conductivity. Lithium tetrahaloaluminates offer an economical option but exhibit low Li conductivities with high activation energy barriers. This study reports the synthesis of lithium aluminum chalcohalide (LiAlClS) using inexpensive precursors one-step mechanochemical milling.
View Article and Find Full Text PDFCationic -Tricarbollide μ-10,11-H-10,11-H-7-MeN--7,8,9-CBH and Its Halogenated Derivatives: The Slow Iodination Process Occurring through Cationic Iodonium Tricarbollides.
Inorg Chem
January 2025
Institute of Inorganic Chemistry, Czech Academy of Sciences, CZ, 250 68 Husinec-Řež, Czech Republic.
A series of -tricarbollides based on 10,11-X-7-MeN--7,8,9-CBH (X = H, Cl, Br, I) and their protonated, i.e. cationic, counterparts, which have an extra H-bridge over the B10-B11 vector in the open pentagonal belt, were prepared.
View Article and Find Full Text PDFIntramolecular Inhibition by Imidazole in Acid-Catalyzed Hydrolysis of Protected Carbohydrates.
Chemistry
December 2024
Eotvos Lorand University, Organic Chemistry, Pazmany Peter Setany 1/A, 1117, Budapest, HUNGARY.
The present study reveals an unexpected anomaly observed in the acid-catalyzed hydrolysis of the 5,6-O-isopropylidene group in 3-O-protected D-gluco- and D-allofuranose derivatives. Although the removal of the 5,6-O-isopropylidene protecting group is typically rapid and quantitative under acidic conditions, an unexpected inhibition of this reaction is observed for the two C3-epimers, 3-O-imidazole sulfonyl moiety. X-ray data show a two-faced imidazole ring orientation in the crystal, while solution state NOE data reveal a critical interaction type between the isopropylidene and the imidazole rings.
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