Background: Prior to cholecystectomy it is important to assess the common duct for choledocholithiasis. Given that a proportion of common duct stones will pass without incident and that methods of removal of these stones are potentially morbid, it would be very useful to have a test that identified only those stones that need intervention. The present study was designed to assess whether a negative magnetic resonance cholangiopancreaticogram (MRCP) is able to reliably exclude clinically relevant common duct stones.
Methods: A retrospective analysis on all patients with cholelithiasis, who underwent MRCP, between November 2001 and May 2003, for suspected choledocholithiasis, was performed. Patients were considered to have no clinically relevant choledocholithiasis if they had a negative MRCP for choledocholithiasis, and were not readmitted to the hospital with complications of choledocholithiasis within a minimum of 3 months after treatment for their cholelithiasis.
Results: The MRCP was negative for choledocholithiasis in 74% of patients (60/81). The MRCP missed clinically relevant choledocholithiasis in only two patients, and had a positive predictive value of 0.95 and a negative predictive value of 0.97 for choledocholithiasis.
Conclusion: In patients with strong indications for choledocholithiasis MRCP is able to reliably exclude clinically relevant choledocholithiasis and is therefore recommended as the preoperative diagnostic imaging tool of choice.
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http://dx.doi.org/10.1111/j.1445-1433.2004.03114.x | DOI Listing |
J Autism Dev Disord
December 2024
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1977 Butler Boulevard, Houston, TX, 77030, USA.
Parent-led cognitive behavioral therapy (CBT) is an efficient, promising form of therapy that may be well suited for autistic youth with anxiety disorders. A recent clinical trial found that parent-led CBT - in which parents led their child through a guided CBT workbook with varying degrees of therapist support - was efficacious for reducing anxiety and associated functional impairment. While such findings demonstrate promise for future intervention development and dissemination efforts with this population, more work is needed to elucidate clinical factors that impact response to treatment as well as drop-out.
View Article and Find Full Text PDFClin Oral Investig
December 2024
Faculty of Dentistry, Department of Restorative Dentistry, Eskisehir Osmangazi University, Eskisehir, Turkey.
Objective: To evaluate the 36-month clinical performance of Single Bond Universal Adhesive (SBU; 3M ESPE, Germany) in non-carious cervical lesions (NCCLs) using different modes of adhesion according to the FDI criteria. The primary outcome was the retention loss of the restorations, while the secondary outcomes included marginal staining, marginal adaptation, post-operative sensitivity and tooth vitality, recurrence of caries erosion and abfraction, and tooth integrity, all evaluated according to the FDI criteria.
Materials And Methods: In this study, the SBU Adhesive was applied to 246 NCCLs of 25 patients using different modes of adhesion: Self-etch (SE), selective-enamel-etching (SLE), and etch-and-rinse (ER).
Ann Hematol
December 2024
Department of Medical Oncology, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Affiliated Hospital of Hebei University, 212 Yuhua East Road, Baoding, 071000, Hebei, China.
The first-line treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has recently undergone major changes, and targeted therapies have ushered in a new era of CLL/SLL treatment. Scientists in different countries have successively analyzed the efficacy of various drugs, but safety studies are relatively insufficient. Therefore, this systematic evaluation and retrospective meta-analysis was conducted to compare the differences in adverse effects and their incidence among first-line treatment regimens for CLL/SLL.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic syndrome is a cluster of some conditions such as high blood sugar, high blood triglycerides, low HDL cholesterol, abdominal obesity, and high blood pressure. Introducing a drug or a food that manages the majority of these medical conditions is invaluable. Tinospora cordifolia, known as guduchi and giloy, is a medicinal herb in ayurvedic medicine that is used in the treatment of various diseased conditions and also as a food for the maintenance of health.
View Article and Find Full Text PDFZ Gerontol Geriatr
December 2024
2. Med. Abteilung, Klinik Landstraße, Juchgasse 25, 1030, Wien, Österreich.
Background: Little is known about how younger and older hospitalized patients differ with respect to reasons for admission, comorbidities, diagnostics, treatment and intercurrent problems.
Objective: The aim of the study was to compare the previously named characteristics in the clinical profile of patients > 90 years old (nonagenarians) with a control group of patients 70-75 years old admitted to an emergency hospital department for internal medicine and cardiology.
Material And Method: The study included all consecutive nonagenarians and gender-matched control patients who were admitted during 2011.
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