AI Article Synopsis
- The study investigated the effects of Brazilian propolis on scratching behavior in ICR mice, finding that propolis granular A.P.C significantly reduced scratching caused by compound 48/80 at high doses, but did not affect histamine-induced scratching.
- Propolis ethanol extract effectively inhibited histamine release from rat mast cells and blocked increased vascular permeability linked to compound 48/80.
- Repeated administration of propolis led to enhanced inhibition of scratching behavior, suggesting its effectiveness relies on a mast cell-dependent mechanism.
Article Abstract
We studied the effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in ICR mice. Propolis granular A.P.C dose-related inhibited scratching behavior induced by compound 48/80 and significant inhibition were observed at 1000 mg/kg. However, histamine-induced scratching behavior was not inhibited by propolis granular A.P.C even at 1000 mg/kg. Propolis ethanol extract at 10 microg/ml or more inhibited histamine release from rat mast cells induced by compound 48/80. In addition, it blocked increased vascular permeability induced by compound 48/80. The inhibitory effect of propolis on scratching behavior induced by compound 48/80 was gradually enhanced by repeated administration, and 500 mg/kg propolis granular A.P.C, which caused no effect through single administration, significantly inhibited scratching behavior after repeated administration for 4 weeks. From these findings, it is assumed that the inhibition of scratching behavior induced by propolis occurs through a mast cell-dependent mechanism.
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| http://dx.doi.org/10.1016/j.intimp.2004.06.007 | DOI Listing |
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