Objective: To investigate the expression of adrenomedullin (ADM) and ADM receptor (ADMR) in epiretinal membranes (ERM) of proliferative vitreoretinopathy (PVR).
Methods: The expression of ADM and ADMR in 10 ERM were studied by in situ hybridization analysis (ISH).
Results: ADM and ADMR mRNAs were expressed in 7 of 10 specimens. The positive signals were distributed unevenly in positive cells. Some cells expressed mainly in the cytoplasm and the others expressed mainly in the nucleus.
Conclusion: ADM and ADMR are expressed in the ERM of PVR, indicating that ADM and ADMR may play a role in the pathogenesis of PVR.
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