Objective: To discuss the pathogenesis of dysosphresia in the chronic sinusitis patients.
Method: Fifty-five cases with chronic sinusitis as experimental group, and 11 cases as control,mere analyzed with acidophilus monitor, and then the P substances in their olfactory mucous were detected.
Result: The positive ratio is 50.9% in the chronic sinusitis patients with dysosphresia, acidophilus monitor in factory mucous was 89.1%. Furthermore, it showed the SP locating in the olfactory cells, support cells, basal cell, glands, epithelium cells of blood vessels, a few of lymphocytes and acidophilus by using the histochemical, immunohistochemical technique (S-P method).
Conclusion: The allergy change of olfactory mucous is one of the main factors that draw olfactory function disorder.
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Adv Sci (Weinh)
January 2025
Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02134, USA.
Natural olfactory systems possess remarkable sensitivity and precision beyond what is currently achievable by engineered gas sensors. Unlike their artificial counterparts, noses are capable of distinguishing scents associated with mixtures of volatile molecules in complex, typically fluctuating environments and can adapt to changes. This perspective examines the multifaceted biological principles that provide olfactory systems their discriminatory prowess, and how these ideas can be ported to the design of electronic noses for substantial improvements in performance across metrics such as sensitivity and ability to speciate chemical mixtures.
View Article and Find Full Text PDFInt Forum Allergy Rhinol
December 2024
Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Background: Quantitative mucus cytokine analysis to examine the sinonasal microenvironment may bridge the gap between patient-reported outcome measures (PROMs) and empirical measures of inflammation in patients with chronic rhinosinusitis (CRS).
Objective: Investigate the correlation between mucus cytokine levels and Sino-Nasal Outcome Test (SNOT-22) scores, including individual subdomains.
Methods: Patients with CRS were prospectively recruited between 2016 and 2021 into a multi-institutional observational study.
J Patient Rep Outcomes
December 2024
Patient-Centered Outcomes, Adelphi Values, Bollington, Cheshire, UK.
Background: PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options. This study assessed content validity and meaningful change in five verbal response scales (VRSs) used to assess chronic rhinosinusitis with nasal polyp (CRSwNP) symptom severity.
Methodology: This qualitative, semi-structured interview study recruited adults from the US, Germany, and China with confirmed moderate-to-severe CRSwNP.
J Rhinol
July 2024
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background And Objectives: The serum galactomannan test (GM test) and the (1,3)-β-D-glucan test (G test) are utilized in diagnosing invasive fungal sinusitis. However, their effectiveness in detecting paranasal sinus fungus balls (FBs) has not been established. This study aimed to explore their diagnostic value in patients with FBs.
View Article and Find Full Text PDFbioRxiv
November 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921.
The sense of smell is generated by electrical currents that are influenced by the concentration of ions in olfactory sensory neurons and mucus. In contrast to the extensive morphological and molecular characterization of sensory neurons, there has been little description of the cells that control ion concentrations in the zebrafish olfactory system. Here, we report the molecular and ultrastructural characterization of zebrafish olfactory ionocytes.
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