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Efficacy and safety of KN026 and docetaxel for HER2-positive breast cancer: a phase II clinical trial.
Cancer Commun (Lond)
January 2025
Department of Medical Oncology, Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, P. R. China.
Background: The standard first-line treatment for human epidermal growth factor receptor 2 (HER2)-positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti-HER2 bispecific antibody, plus docetaxel in first-line treatment of HER2-positive recurrent/metastatic breast cancer.
Methods: This open-label, single-arm, phase II study enrolled patients with HER2-positive recurrent/metastatic breast cancer in 19 centers across China from December 30, 2019 to May 27, 2021.
Progressive Cachexia: Tuberculosis, Cancer, or Thyrotoxicosis? Disease-Directed Therapy and Atypical Courses of Autoimmune and Malignant Thyroid Diseases in a High Specialization Era: Case-Control Study with a Critical Literature Review.
Biomedicines
November 2024
Department of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, 50-367 Wrocław, Poland.
Critical and progressive cachexia may be observed in numerous medical disciplines, but in patients with various diseases, several pathways overlap (endocrine, inflammatory and kidney diseases, heart failure, cancer). Unlike numerous cohort studies that examine thyroid cancer and risk factors, a different method was used to avoid bias and analyze the sequence of events, i.e.
View Article and Find Full Text PDFAtypical presentation of disseminated mycobacteriosis due to Mycobacterium avium in an aged cat.
Aust Vet J
December 2024
Centre for Veterinary Education, The University of Sydney, Sydney, Australia.
In cats, mycobacteriosis tends to present in a syndromic manner, with cases either being due to tuberculosis (TB) (in countries where TB is endemic), one of the "leprosy-like" diseases affecting the skin and subcutis, panniculitis caused by infection of subcutaneous tissues generally with rapidly growing Mycobacteria spp. or widely disseminated granulomatous disease, which is usually caused by members of the Mycobacterium avium-intracellulare complex (MAC). Disseminated MAC disease is rare, but when it occurs, usually develops in immunocompromised hosts with defective cell-mediated immunity.
View Article and Find Full Text PDFPericardial effusion in an Indian context: clinical insights and dynamics from a tertiary care centre.
BMC Cardiovasc Disord
December 2024
Faculty of General Medicine, Department of General Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Background: Pericardial effusion (PE) indicates the build-up of fluid within the pericardial sac, which encases the heart. The present study was undertaken to assess the clinical profile, etiology of pericardial effusion and to determine the correlation of cardiac tamponade and constrictive pericarditis with etiology.
Methods: A prospective observational hospital based longitudinal study was undertaken among the 88 newly diagnosed and known patients of pericardial effusion who are above 18 years.
Metastatic parathyroid carcinoma diagnosed after five surgical attempts: a case report and review of the literature.
J Cardiothorac Surg
December 2024
Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- * A 45-year-old woman, initially diagnosed with parathyroid adenoma, experienced a rise in hormone levels 2.5 years post-surgery, leading to further unsuccessful treatments before being referred for additional investigation.
- * Ultimately, the diagnosis of parathyroid carcinoma was made after exploring the mediastinum, revealing metastases rather than the expected thyroid cancer spread, underscoring the need for careful follow-up in hyperparathyroidism cases.
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