AI Article Synopsis
- Chronic mild stress (CMS) in rats serves as a model for studying depression and anhedonia (the inability to feel pleasure).
- After 4 weeks of CMS, researchers measured the activation of neurons in the nucleus accumbens (NAc) following sucrose consumption.
- Results showed that CMS rats had significantly fewer activated neurons (Fos-positive neurons) in the NAc compared to control rats, suggesting a biological basis for decreased responses to rewarding stimuli in depression.
Article Abstract
Chronic mild stress (CMS), an animal model of depression associated with anhedonia, was used to examine nucleus accumbens (NAc) activation associated with a rewarding stimulus. Following 4 weeks of CMS in rats, NAc Fos-immunoreactivity was measured after ingestion of a fixed volume of sucrose. Fewer Fos-positive neurons were observed in the NAc in CMS versus control rats. These findings have implications for the mechanisms underlying reduced responding to pleasurable stimuli associated with depression.
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| http://dx.doi.org/10.1016/j.brainres.2004.05.019 | DOI Listing |
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