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Myoelectric prosthetic hands are typically controlled to move between discrete positions and do not provide sensory feedback to the user. In this work, we present and evaluate a closed-loop, continuous myoelectric prosthetic hand controller, that can continuously control the position of multiple degrees of freedom of a prosthesis while rendering proprioceptive feedback to the user via a haptic feedback armband. Twenty-eight participants without and ten participants with upper limb difference (ULD) were recruited to holistically evaluate the physical and psychological effects of the controller via isolated control and sensory tasks, dexterity assessments, embodiment and task load questionnaires, and post-study interviews.
View Article and Find Full Text PDFEndovascular Coiling Combined With Tissue Glue Embolism to Treat 20 Cases of Iliac Arteriovenous Fistula Secondary to Deep Vein Thrombosis.
J Endovasc Ther
January 2025
Department of Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Objective: The objective of this study is to assess the feasibility of endovascular coiling combined with tissue glue embolism for the treatment of iliac arteriovenous fistula (AVF) secondary to deep vein thrombosis (DVT) of the lower extremities. In addition, we aim to summarize the treatment methods and enhance understanding of the disease.
Methods: This research analyzes the clinical data and medical imaging materials of 20 cases with iliac AVF secondary to lower extremity DVT, ranging from December 2014 to December 2020, at our hospital.
Endothelial Dysfunction in Acute Myocardial Infarction: A Complex Association With Sleep Health, Traditional Cardiovascular Risk Factors and Prognostic Markers.
Clin Cardiol
January 2025
Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Sfax, Tunisia.
Background: Endothelial function (EndFx) is a core component of cardiovascular (CV) health and cardioprotection following acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI).
Hypothesis: AMI patients experience endothelial dysfunction (EndDys), associated with traditional CV risk factors and sleep patterns. EndFx may also predict short and mid-term outcomes.
Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations.
J Med Chem
January 2025
Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
Despite recent advances in the inhibition of EGFR (epidermal growth factor receptor), there remains a clinical need for new EGFR Exon20 insertion (Ex20Ins) inhibitors that spare EGFR WT. Herein, we report the discovery and optimization of two chemical series leading to ether and biaryl as potent, selective, and brain-penetrant inhibitors of Ex20Ins mutants. Building on our earlier discovery of alkyne which allowed access to CNS property space for an Ex20Ins inhibitor, we utilized structure-based design to move to lower lipophilicity and lower CL compounds while maintaining a WT selectivity margin.
View Article and Find Full Text PDFKinematic Alignment Compared with Mechanical Alignment Techniques Results in Greater Peak Three-Dimensional Knee Joint Moments During Stair Negotiation.
J Arthroplasty
January 2025
The University of Tennessee Health Science Center-Campbell Clinic Department of Orthopaedic Surgery and Biomedical Engineering, 1400 S. Germantown Rd, Germantown, TN, 38138. Electronic address:
Background: This study investigated the influence of surgical alignment techniques on knee joint biomechanics during stair negotiation tasks. Our hypothesis was that a more personalized joint alignment would result in reduced medial knee loading biomechanics to negotiate the stairs.
Methods: There were 28 adults (14 mechanical alignments [MA], 14 kinematic alignment [KA]) who underwent total knee arthroplasty (TKA) at least one year post-operatively and performed five stair ascent and descent trials at their preferred velocities.
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