AI Article Synopsis
- A new method for asymmetric hydrogenation of unprotected enamino esters and amides is introduced.
- This process is catalyzed by Rh complexes paired with Josiphos-type chiral ligands, leading to successful production of beta-amino esters and amides.
- The method achieves high yields and excellent enantiomeric excess (93-97% ee) without needing acyl protection or deprotection.
Article Abstract
A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos-type chiral ligands, this method gives beta-amino esters and amides in high yield and high ee (93-97% ee). No acyl protection/deprotection is required.
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| http://dx.doi.org/10.1021/ja047901i | DOI Listing |
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