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Using N-of-1 trials to improve patient management and save costs.
J Gen Intern Med
September 2010
Health Economics, School of Medicine, Griffith University, Brisbane, Queensland, Australia.
Background: N-of-1 trials test treatment effectiveness within an individual patient.
Objective: To assess (i) the impact of three different N-of-1 trials on both clinical and economic outcomes over 12 months and (ii) whether the use of N-of-1 trials to target patients' access to high-cost drugs might be cost-effective in Australia.
Design: Descriptive study of management change, persistence, and costs summarizing three N-of-1 trials.
Do individualized medication effectiveness tests (n-of-1 trials) change clinical decisions about which drugs to use for osteoarthritis and chronic pain?
Am J Ther
April 2005
Discipline of General Practice, The University of Queensland, Herston, Queensland, Australia.
To assess the impact of individualized medication effectiveness tests (IMETs, or n-of-1 trials), on patients' short-term decision making about medications for chronic pain. Survey evaluation of patients undergoing a double-blind, crossover comparison of drug versus placebo, drug versus drug, or drug versus drug combination using paracetamol and ibuprofen in 3 pairs of treatment periods, randomized within pairs. General practice patients (supplemented by a few from 2 tertiary pain clinics) with either chronic pain (> or =3 months), or osteoarthritis (with pain for > or =1 month) severe enough to warrant consideration of long-term nonsteroidal antiinflammatory drug (NSAID) use but for whom there was doubt about the efficacy of NSAID or alternative.
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