Canine visceral leishmaniasis (CVL) is a zoonosis and a chronic systemic disease of the dog caused by a protozoan of the genus Leishmania. In the New World, the disease is caused by the species Leishmania (Leishmania) chagasi. There are only a few studies on the histopathology of lymph nodes in canine leishmaniasis. In the present paper, we report a histopathological description of lymph nodes considering animals with a defined clinical status and the parasite burden of lymph node tissues. Forty-eight mongrel dogs naturally infected with L. chagasi, were obtained from two endemic areas of Brazil. Cervical, axillary and popliteal lymph nodes were analyzed. The parasite burden, expressed as "Leishman-Donovan units", was variable among the defined types of clinical condition. Asymptomatic dogs can show higher parasitism than oligosymptomatic or symptomatic animals. Grossly, a generalized lymphadenopathy was found, but it was mainly observed in cervical and popliteal nodes. Histologically, the increased number and size of lymphoid follicles, and the marked hypertrophy and hyperplasia of medullary macrophages (cords and sinus) explained the lymphadenopathy. In addition, the clinical status or the tissue parasitism load might not be directly related to the intensity of the lesions.
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