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Machine learning in personalized laryngeal cancer management: insights into clinical characteristics, therapeutic options, and survival predictions.
Eur Arch Otorhinolaryngol
December 2024
King Hussein Cancer Center, Medical Oncology Department, Amman, Jordan.
Purpose: Over the last 40 years, there has been an unusual trend where, even though there are more varied treatments, survival rates have not improved much. Our study used survival analysis and machine learning (ML) to investigate this odd situation and to improve prediction methods for treating non-metastatic LSCC.
Methods: The surveillance, epidemiology and end results (SEER) database provided the data used for this study's analysis.
Individual- and community-level correlates of intermittent preventive treatment of malaria in pregnancy in Ghana: further analysis of the 2019 Malaria Indicator Survey.
Res Health Serv Reg
December 2024
Directorate of Academic Planning and Quality Assurance, University of Cape Coast, Cape Coast, Ghana.
Background: Ghana adopted the policy on Intermittent Preventive Treatment of malaria in pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) in 2004. Notwithstanding the government's and other stakeholders' efforts in Ghana, optimal uptake (three or more doses of IPTp-SP) has slightly declined since 2016. The study examined the individual and community-level correlates of pregnant women who take optimal or none/partial doses (less than three doses) of IPTp-SP using the Ghana Malaria Indicator Survey (GMIS) 2019.
View Article and Find Full Text PDFEvaluation of urinary vanin-1 for the early prediction of cisplatin-induced acute kidney injury during neoadjuvant chemotherapy for esophageal cancer.
Cancer Chemother Pharmacol
December 2024
Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Purpose: Cisplatin (CDDP) induces acute kidney injury (AKI) as a side effect during neoadjuvant chemotherapy (NAC). Urinary vanin-1 excretion may increase during CDDP treatment. We investigated whether urinary vanin-1 is an early biomarker for CDDP-induced AKI.
View Article and Find Full Text PDFAlterations in Response Switching in Parkinson's Disease: New Insights Into Cueing.
J Geriatr Psychiatry Neurol
December 2024
Laboratory for Early Markers of Neurodegeneration (LEMON), Center for the Study of Movement, Cognition, and Mobility (CMCM), Tel Aviv Sourasky Medical Center, Neurological Institute, Tel Aviv, Israel.
Switching, a critical executive function, can manifest as task switching (TS) or response switching (RS). Although TS impairments in Parkinson's disease (PD) are well-studied, RS, especially in contexts requiring adaptive behavior to external or internal cues, is less explored. This study evaluated the impact of PD on RS under exogenous and endogenous cueing.
View Article and Find Full Text PDFPredicting Persistent Reduced Physical Performance in Adults 65+ in Emergency Departments: A Temporal Validation.
J Geriatr Phys Ther
December 2024
Department of Public Health, University of Southern Denmark, Odense, Denmark.
Background And Purpose: Targeted interventions to maintain physical performance in older adults are important. We aimed to validate an existing 4-item prediction model and, if necessary, develop a new model for early identification of adults aged 65+ with persistent reduced physical performance.
Methods: A temporal validation study on adults aged 65+ admitted to the emergency department for medical reasons and who performed ≤8 repetitions in the 30-second chair-stand test (30s-CST) within the first 48 hours of admission.
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