Symptomatic antiepileptic drug associated vitamin D deficiency in noninstitutionalized patients: an under-diagnosed disorder.

J Med Liban

Department of Pediatrics/Adult and Pediatric Epilepsy Program, American University of Beirut, 3 Dag Hammarskjold Plaza, 8th Floor, New York, NY 10017-2303, USA.

Published: October 2004

AI Article Synopsis

  • Four noninstitutionalized epilepsy patients, aged 4 months to 51 years, developed severe vitamin D deficiency due to long-term use of antiepileptic medications.
  • Symptoms included increased seizure frequency, status epilepticus, muscle spasms, and bone-related issues like fractures and osteomalacia.
  • The findings highlight the importance of regularly screening epilepsy patients on chronic antiepileptic drugs for vitamin D and calcium deficiencies.

Article Abstract

Four noninstitutionalized patients, 4 months - 51 years old, presented out of 421 patients with epilepsy seen within a period of 2 years with serious symptoms of vitamin D deficiency secondary to chronic antiepileptic drug therapy. Presenting symptoms included exacerbation of seizure activity, status epilepticus, carpopedal spasms, fractures, osteomalacia, and rickets. All had low serum calcium and low vitamin D levels. Our experience supports the practice of screening patients on chronic antiepileptic drug therapy for vitamin D abnormalities.

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