In vivo acquisition of high-level resistance to imipenem in Escherichia coli.

J Clin Microbiol

Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 Rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France.

Published: August 2004

Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC497580PMC
http://dx.doi.org/10.1128/JCM.42.8.3831-3833.2004DOI Listing

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