AI Article Synopsis
- A new method was developed to synthesize 6H-indolo[2, 3-b][1, 8]naphthyridine derivatives from 2-chloro-1, 8-naphthyridines.
- The synthesized compounds were tested on 55 tumor cell lines to evaluate their anticancer effects.
- The presence of an acetylamino group at position 3 of the ring system was found to be essential for the compounds' ability to inhibit cancer cell growth.
Article Abstract
The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2-chloro-1, 8-naphthyridines. The synthesized 6H-indolo[2, 3-b][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.
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| http://dx.doi.org/10.1002/ardp.200200696 | DOI Listing |
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