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Differences in Drug Shortages in the US and Canada.
JAMA
December 2024
Division of General Internal Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Importance: Drug shortages are a persistent public health issue that increased during the COVID-19 pandemic. Both the US and Canada follow similar regulatory standards and require reporting of drug-related supply chain issues that may result in shortages. However, it is unknown what proportion are associated with meaningful shortages (defined by a significant decrease in drug supply) and whether differences exist between Canada and the US.
View Article and Find Full Text PDFA tertiary care centre experience with Elranatamab: A report of three cases.
Leuk Res Rep
June 2024
Department of Haemat-oncology, Rajiv Gandhi cancer institute and research centre, New Delhi, India.
Article Synopsis
- The introduction of new treatments like proteasome inhibitors and monoclonal antibodies has significantly improved life expectancy for multiple myeloma patients, but there's a need for better therapies, particularly for those with triple-class refractory disease.
- Elranatamab, a bispecific antibody, is commonly used in India for treating this condition, though data on its effectiveness in real-world settings is lacking.
- In a small case report of three patients receiving elranatamab monotherapy, common side effects included mild cytokine release syndrome and cytopenias, with one patient experiencing severe neurological toxicity, highlighting the need for ongoing assessment of treatment safety and efficacy.
0.01% Atropine Eye Drops in Children With Myopia and Intermittent Exotropia: The AMIXT Randomized Clinical Trial.
JAMA Ophthalmol
August 2024
Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Importance: Exotropia and myopia are commonly coexistent. However, evidence is limited regarding atropine interventions for myopia control in children with myopia and intermittent exotropia (IXT).
Objective: To evaluate the efficacy and safety of 0.
Not Just Another Reporting Guideline? Here's Why READUS-PV is a Major Step Forward.
Drug Saf
June 2024
Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
Local Impact From International Crises: Unregulated Drug Toxicity During the COVID-19 Pandemic in British Columbia, Canada.
Am J Public Health
June 2024
Samuel Tobias is with the School of Population and Public Health, University of British Columbia, and the British Columbia Centre on Substance Use, Vancouver, Canada. Jane A. Buxton is with the School of Population and Public Health, University of British Columbia. Lianping Ti is with the Department of Medicine, University of British Columbia, and the British Columbia Centre on Substance Use.
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