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Just the facts: considerations and management of fever in the returning traveler.
CJEM
January 2025
Department of Emergency Medicine, University of British Columbia, Vancouver, BC, Canada.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Institute of Transformative Molecular Medicine, Case western Reserve University, Cleveland, OH, USA.
Background: Alzheimer's disease (AD) is a severe neurodegenerative condition that affects millions of people worldwide. The TgF344 AD rat model, which exhibits early depression-like behavior followed by later cognitive impairment, is widely used to evaluate putative biomarkers and potential treatments for AD. The P7C3 neuroprotective compounds have shown protective efficacy for both brain pathology and neuropsychiatric impairment in this model.
View Article and Find Full Text PDFBackground: Early detection and accurate forecasting of AD progression are crucial for timely intervention and management. This study leverages multi-modal data, including MRI scans, brain volumetrics, and clinical notes, utilizing Machine Learning (ML), Deep Learning (DL) and a range of ensemble methods to enhance the forecasting accuracy of Alzheimer's disease.
Method: We utilize the OASIS-3 longitudinal dataset, tracking 1,098 patients over 30 years.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Cellular senescence, which can cause significant changes in morphology, metabolism, and function, is a key contributor to aging and diseases including Alzheimer's Disease (AD). Accurate biomarker identification is essential for detecting senescent cells. Our research aims at defining gene signatures that encapsulate senescence complexity in the brain.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Institute of Neuroscience - UCLouvain, Brussels, Belgium.
Background: The medial temporal lobe (MTL) is the first cortical region affected by tauopathy in Alzheimer's disease (AD) and is implicated in spatial orientation. In early AD stages, navigation deficits, including path integration deficits, could be present, even before memory deficits. We investigated whether these deficits were related to AD pathology (amyloidosis and/or tauopathy) using a path integration task, the "Apple Game".
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