Objective: To synthesize N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives and investigate their antitumor activities.
Methods: Title compounds (I) were prepared by 5-fluorouracil which was trimethylsilylated by hexamethyl-di-silazane, and then acylated. Hydrogenization of compounds (I) brought on compounds (II), which were esterified to produce title compounds (III) afterwards.
Results: Twelve title compounds were synthesized.
Conclusion: These compounds were designed products confirmed by 1H-NMR, IR and MS spectral data.
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