AI Article Synopsis
- The study investigates congenital hypertrophy of the retinal pigment epithelium (CHRPE) in patients with familial adenomatous polyposis (FAP) to determine predictive properties and associations with FAP variants.
- Researchers analyzed 286 participants, comparing FAP patients and those "at risk" with control subjects, noting that affected individuals typically had more lesions with specific characteristics than controls.
- Despite CHRPE’s prevalence among FAP patients, the results indicated no unique CHRPE traits tied to specific FAP variants, suggesting a shared genetic basis for the observed retinal abnormalities.
Article Abstract
Background: Several kinds of congenital hypertrophy of the retinal pigment epithelium (CHRPE) have been described in patients with familial adenomatous polyposis (FAP). This study aims to assess which properties of CHRPE better predict FAP and investigate whether a relationship exists between specific CHRPE characteristics and FAP variants.
Methods: We examined 286 subjects, Group I--patients with FAP plus individuals "at risk"; n = 173; Group II--controls n = 113. Retinal lesions were classified in five types (A-E) and different characteristics (distribution, number, shape, size, pigmentation and site) were evaluated.
Results: The most common lesions in affected subjects were types A-D (83.4%) whilst in the "at risk" and control groups were type E. Greater numbers of lesions and bilateral distribution occurred more frequently among affected subjects than in other participants (p < 0.001). Large lesions with mixed pigmentation were associated with polyposis (p > 0.5). Controls had solitary CHRPE lesions (3.5%) and types C and E lesions (23%). The cumulative sensitivities and specificities of CHRPE were 42 and 97%, respectively. CHRPE was most common among those with classical FAP, but no specific characteristic was associated with any particular FAP variant.
Conclusions: Pigmented fundal lesions are highly pleomorphic and represent the variable expression of a common genetic defect of growth regulation. No association was found between CHRPE characteristics and specific FAP variants.
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| http://dx.doi.org/10.1023/b:inte.0000031739.62559.ac | DOI Listing |
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