Bilaterally identical monoclonality in a case of primary intraocular lymphoma.

Purpose: To report a case of primary intraocular lymphoma possessing bilaterally identical monoclonal rearrangements of the immunoglobulin heavy chain (IgH) gene.

Design: Observational case report.

Methods: A 78-year-old woman with bilateral vitritis, subretinal infiltrates in the right eye, and no involvement of the central nervous system (CNS) was diagnosed histologically with diffuse large B-cell lymphoma by a transvitreal subretinal biopsy of the right eye. One month later, vitrectomy was performed on the left eye due to increased vitreous opacity. DNA was extracted from a vitrectomy specimen from each eye, and the third complementarity-determining region of IgH gene was analyzed by polymerase chain reaction and direct sequencing.

Results: Monoclonal rearrangements of IgH gene with identical DNA sequence were detected in both eyes.

Conclusions: Bilaterally identical monoclonality was detected in a case of primary intraocular lymphoma with no CNS involvement.