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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial.
Health Technol Assess
January 2025
School of Medicine, Keele University, Keele, Staffordshire, UK.
Background: For people receiving haemodialysis, a balance has to be struck between removing sufficient but not too much fluid during a treatment session and maintaining any remaining kidney function they might have. In the BISTRO trial, this study sought to establish if getting the balance right might be improved by the additional use of bioimpedance, a device that measures body fluid composition to help decide how much fluid to remove during dialysis. Designing and executing this trial, which incorporated complex and repeated trial procedures that would be dependent on participant engagement, presented challenges that demanded effective public and patient involvement.
View Article and Find Full Text PDFProjected changes to drought characteristics in Tehran under CMIP6 SSP-RCP climate change scenarios.
Heliyon
January 2025
Department of Civil Engineering, Payame Noor University, Tehran, Iran.
Drought represents one of the most devastating natural hazards, significantly impacting economies, societies, and the environment. Climate change is expected to alter future drought characteristics and may increase the severity of droughts. To mitigate these effects, it is essential to identify the characteristics of future droughts influenced by climate change using appropriate methods.
View Article and Find Full Text PDFEvaluating the effectiveness of genicular radiofrequency ablation for chronic knee pain using the patient-reported outcomes measurement information system (PROMIS) global health-physical health domain: Results of a cross-sectional cohort study.
Interv Pain Med
March 2025
Department of Physical Medicine and Rehabilitation, University of Utah School of Medicine, Salt Lake City, UT, USA.
Objective: Evaluate the effectiveness of genicular nerve radiofrequency ablation (GNRFA) for chronic knee pain using the Patient-Reported Outcomes Measurement Information System Global Health, Physical Health score (PROMIS-GH-PH).
Methods: Patients who underwent GNRFA at a tertiary academic center were identified by CPT code query and contacted for consent. Demographic, clinical, and procedural characteristics were collected from the electronic medical record of participants with baseline PROMIS-GH-PH scores.
Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients.
Front Immunol
January 2025
Aix-Marseille Université, INSERM, INRAE, C2VN, Marseille, France.
Rationale: COVID-19-associated acute-respiratory distress syndrome (C-ARDS) results from a direct viral injury associated with host excessive innate immune response mainly affecting the lungs. However, cytokine profile in the lung compartment of C-ARDS patients has not been widely studied, nor compared to non-COVID related ARDS (NC-ARDS).
Objectives: To evaluate caspase-1 activation, IL-1 signature, and other inflammatory cytokine pathways associated with tissue damage using post-mortem lung tissues, bronchoalveolar lavage fluids (BALF), and serum across the spectrum of COVID-19 severity.
Unlabelled: Macroeconomic conditions significantly affect consumer spending patterns, including aesthetic surgery expenditures. This study examines the longitudinal relationship between unemployment rates, disposable income, stock indices, and aesthetic surgery spending from 2006 to 2019. Data on aesthetic surgery expenditures were collected from the American Society of Plastic Surgeons, whereas unemployment data were obtained from the US Bureau of Labor Statistics, disposable income from the US Bureau of Economic Analysis, and stock indices from the Federal Reserve Economic Data.
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