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CLINICAL EFFICACY OF ORAL AZITHROMYCIN VERSUS OTHER ANTIMICROBIAL DRUGS IN THE TREATMENT OF TYPHOID PATIENTS ACROSS ALL AGE GROUPS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS.
J Ayub Med Coll Abbottabad
December 2024
Federal Medical College, Islamabad-Pakistan.
Background: Typhoid is a major health concern. Drug-resistant cases of typhoid have given rise to new debates. Azithromycin has shown adequate results.
View Article and Find Full Text PDFNasal carriage of MRSA among clinically affiliated undergraduate students at the College of Health and Medical Sciences, Haramaya University, Ethiopia.
Sci Rep
December 2024
School of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Medical and health science students are among the demographics most at risk from Methicillin-resistant Staphylococcus aureus (MRSA), which is a serious hazard to public health. The main reservoir for MRSA is the nasal cavity, and colonization of this area can raise the risk of infection and transmission in healthcare settings. This study aimed to assess the nasal carriage rate of MRSA among clinically affiliated students at Haramaya University, College of Health and Medicine Sciences, Ethiopia, from July to August 2022.
View Article and Find Full Text PDFNon-typhoidal in humans in India, Vietnam, Bangladesh and Sri Lanka: a systematic review.
JAC Antimicrob Resist
December 2024
Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK.
Objectives: Non-typhoidal (NTS) commonly causes a self-limiting illness but invasive disease (iNTS) can be life-threatening. Antimicrobial resistance (AMR) increases the risk of mortality. This systematic review aimed to estimate the proportion of NTS isolated in those attending healthcare services, serovar burden, AMR, serovar-specific AMR, and case fatality rate (CFR) in India, Bangladesh, Sri Lanka and Vietnam.
View Article and Find Full Text PDFDiloxanide in amoebiasis management: Unravelling the mechanism of action and effectiveness.
Basic Clin Pharmacol Toxicol
January 2025
Department of Pharmacy, Faculty of Pharmacy, Universitas Borneo Lestari, Banjarbaru, Indonesia.
Article Synopsis
- Diloxanide is an effective treatment for asymptomatic amoebiasis, but its exact mechanism of action is not well understood despite its structural similarities to chloramphenicol.
- It operates by inhibiting protein synthesis in the E. histolytica parasite, preventing the formation of more virulent cysts, and achieving a parasite clearance rate of 81-96%.
- The study calls for further research into diloxanide's structure-activity relationship and suggests exploring new drug formulations and improved diagnostic methods to enhance treatment efficacy and reduce the risk of relapse.
Exposure factors associated with antimicrobial resistance and identification of management practices for preharvest mitigation along broiler production systems: A systematic review.
J Glob Antimicrob Resist
December 2024
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA. Electronic address:
Objective: This systematic review aimed to (i) determine the risk of antimicrobial resistance (AMR) development associated with antimicrobial use (AMU) and other exposure factors in broilers, and (ii) identify best management practices to mitigate preharvest AMR development of enteric bacteria alongside broiler production.
Methods: Study selection criteria comprised the population, exposure or intervention, comparator, and outcome framework and included broiler (population), AMU or other management practices (exposure or intervention), organic or antibiotic-free production (comparator), and the presence of AMR-enteric bacteria/genes (outcome). Peer-reviewed primary research studies were searched in PubMed on 19 December 2022, and AGRICOLA, Embase, Scopus, and Web of Science on 10 February 2023.
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