Objective: The purpose of this study was to create a novel animal model for studies of endometriosis.
Study Design: To facilitate the study of the transplantation of endometriosis into immunodeficient RAG-2/gamma(c)KO mice, endometriosis biopsy specimens were collected from 19 women by laparoscopic surgery and grafted subcutaneously into the mice, which were treated subsequently with estradiol and progesterone to create 28-day artificial cycles. The grafts were collected during the first, second, and fourth cycles and were evaluated histologically for evidence of bleeding and immunocytochemically for estrogen receptor and progesterone receptor.
Results: Biopsy specimens that contained endometrium-like glands were well accepted (>90% success). These grafts maintained glandular morphologic condition, estrogen receptor, and progesterone receptor; bled after progesterone withdrawal; and formed chocolate cysts. However, biopsy specimens that lacked glands or that consisted of peritoneal adhesions and stroma were accepted poorly <5% success) and failed to show evidence of estrogen receptor, progesterone receptor, or cyclic bleeding.
Conclusion: Human endometriosis transplanted into RAG-2/gamma(c)KO mice can provide a model for endometriotic bleeding.
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http://dx.doi.org/10.1016/j.ajog.2004.02.047 | DOI Listing |
BMC Cancer
January 2025
Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Background: Gastric cancer peritoneal metastasis lacks effective predictive indices. This article retrospectively explored predictive values of DNA ploidy, stroma, and nucleotyping in gastric cancer peritoneal metastasis.
Methods: A comprehensive analysis was conducted on specimens obtained from 80 gastric cancer patients who underwent gastric resection at the Department of Gastrointestinal Surgery of Wuhan University Renmin Hospital.
Mod Pathol
January 2025
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:
Oxyntic gland neoplasms typically arise in Helicobacter pylori-naïve stomachs and are composed predominantly of chief cells, with a smaller component of parietal cells. The pathologic diagnosis can be challenging due to minimal cellular atypia. Especially in biopsy specimens with limited tumor volume or when pathologists have limited experience in diagnosing this neoplasm, distinguishing it from normal oxyntic glands can be difficult, and no reliable diagnostic markers are currently available.
View Article and Find Full Text PDFMod Pathol
January 2025
Bielefeld University, Medical School and University Medical Center OWL, Lung Cancer Center Lippe, Department of Pathology, Klinikum Lippe Detmold, 32756 Detmold, Germany. Electronic address:
Intraoperative consultation is frequently used during the surgical treatment of lung tumors for the diagnosis of malignancy and the assessment of surgical margins. The latter is often problematic given the nature of the applied staple lines, which cannot be readily examined in frozen sections. Seventy-nine samples of surgical margins (71 staple lines and 8 open margins) from 52 lung specimens were examined using an ex vivo fluorescence confocal microscope (FCM).
View Article and Find Full Text PDFInt J Surg Case Rep
January 2025
Breast and Endocrine Surgery Consultant, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
Introduction And Importance: Accessory breast is a rare condition where regression of the mammary ridge fails. This ectopic breast can function as the same pectoral breast and respond to hormonal effects. Furthermore, in rare cases, it can develop into malignancy.
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
February 2025
Department of Pathology, the First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
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