A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis. | LitMetric

Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis.

Blood

Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital Saint Louis, IUH, 1, avenue Claude Vellefaux, 75010 Paris, France.

Published: November 2004

AI Article Synopsis

  • Researchers have clarified the role of a new marker, HLA-G, in the early development of blood (hematopoiesis) and blood vessel (endothelial) formation in human embryos.
  • HLA-G is found in primitive erythroid cells and endothelial cells, and exists in a soluble form as HLA-G5 in various organs involved in early blood cell development.
  • The study suggests that HLA-G5 may play a role in the differentiation of blood cells and the formation of blood vessels, providing insights into both primitive and definitive erythropoiesis.

Article Abstract

The initial steps of primitive hematopoiesis and endothelial vascular formation in the human embryo remain to be defined. Here, we report the identification of a novel marker, namely the nonclassical HLA-G class I molecule, which targets both primitive erythroid cells of the yolk sac and endothelial cells from developing vessels. Moreover, HLA-G was present in its soluble form in the erythropoietic lineage in all organs sustaining primitive to definitive erythropoiesis (ie, aorta-gonad-mesonephros, liver, spleen, and bone marrow). The alternatively spliced transcript coding the soluble HLA-G5 molecule was detected in erythroid cells. The corresponding intron 4-retaining 37-kDa HLA-G5 isoform was secreted from the erythroid progenitor stage to the reticulocyte but was lost in mature erythrocytes and in endothelial cells from differentiated vessels. This study constitutes the first description of an HLA class I antigen expression on the primitive erythroid lineage and provides a way of seeking both primitive and definitive erythropoiesis using HLA-G5. This new marker, previously known by its immunotolerogeneic properties, may be involved in erythroid differentiation, angiogenesis, or both.

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2004-03-0809DOI Listing

Publication Analysis

Top Keywords

primitive definitive
12
nonclassical hla-g
8
primitive erythroid
8
erythroid cells
8
endothelial cells
8
definitive erythropoiesis
8
primitive
6
erythroid
5
erythroblasts secrete
4
secrete nonclassical
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!