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Synchronization stability of epileptic brain network with higher-order interactions.
Chaos
January 2025
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Generally, epilepsy is considered as abnormally enhanced neuronal excitability and synchronization. So far, previous studies on the synchronization of epileptic brain networks mainly focused on the synchronization strength, but the synchronization stability has not yet been explored as deserved. In this paper, we propose a novel idea to construct a hypergraph brain network (HGBN) based on phase synchronization.
View Article and Find Full Text PDFTreatment failure and the threshold of disease extinction.
Infect Dis Model
June 2025
Department of Mathematics, Faculty of Science, Silpakorn Universtiy, Nakhon Pathom Province, 73000, Thailand.
Antibiotic treatment failure related to carriers poses a serious problem to physicians and epidemiologists. Due to the sparsity of data, assessing the role in infection dynamics is difficult. In this study, we examined the possibility that a particular therapeutic effectiveness will be regarded as the disease extinction threshold through the mathematical modelling approach.
View Article and Find Full Text PDFInsight into dipeptidase 1: structure, function, and mechanism in gastrointestinal cancer diseases.
Transl Cancer Res
December 2024
Department of Oncology, Jiangdu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Dipeptidase 1 (DPEP1), initially identified as a renal membrane enzyme in mature human kidneys, plays a pivotal role in various cellular processes. It facilitates the exchange of materials and signal transduction across cell membranes, contributing significantly to dipeptide hydrolysis, glucose and lipid metabolism, immune inflammation, and ferroptosis, among other cellular functions. Extensive research has delineated the complex role of DPEP1 in oncogenesis and tumor progression, with its influence being context dependent.
View Article and Find Full Text PDFGIS-based assessment of photovoltaic solar potential on building rooftops in equatorial urban areas.
Heliyon
January 2025
Universidad de Cuenca, Laboratorio de Ecología Acuática (LEA), Balzay Campus, Cuenca, 010107, Ecuador.
Installing photovoltaic systems (PVs) on building rooftops is a viable and sustainable alternative to meet the growing demand for electricity in cities. This work develops a methodology that uses LiDAR (laser imaging detection and ranging) technology and roof footprints to obtain a three-dimensional representation of the rooftops in the urban centre of Santa Isabel (Azuay, Ecuador). This allowed the determination of characteristics such as area, slope, orientation, and received solar radiation, making it possible to calculate the rooftop's theoretical, technical, and economic photovoltaic potential.
View Article and Find Full Text PDFChemical imaging unveils mitochondria as the major site of medicinal biguanide accumulation within cells.
Heliyon
July 2024
School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Metformin (MET), a commonly prescribed medication for managing type 2 diabetes, has demonstrated various beneficial effects beyond its primary anti-diabetic efficacy. However, the mechanism underlying MET activity and its distribution within organelles remain largely unknown. In this study, we integrate multiple technologies, including chemical labeling, immunostaining, and high-resolution microscopy imaging, to visualize the accumulation of MET in organelles of cultured cells.
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