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TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality.
Gut
November 2024
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Article Synopsis
- PARP inhibitors have been approved for maintenance therapy in metastatic pancreatic cancer patients with rare BRCA1/2 mutations, highlighting a significant unmet need for broader applications.* -
- Research involved RNA sequencing to identify potential targets for PARPi sensitivity, verifying that targeting TPX2 can increase vulnerability to these inhibitors and promote synthetic lethality in various cancer models.* -
- TPX2 plays a crucial role in the DNA repair process, and manipulating its phosphorylation status enhances PARPi sensitivity and contributes to genomic instability, suggesting that combining TPX2 inhibition with other therapies like gemcitabine could improve treatment effectiveness.*
Glyphosate formulations cause mortality and diverse sublethal defects during embryonic development of the amphibian Xenopuslaevis.
Chemosphere
November 2024
Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany. Electronic address:
The human impact on environmental landscapes, such as land use, climate change or pollution, is threatening global biodiversity and ecosystems maintenance. Pesticides like the herbicide glyphosate have garnered considerable attention due to their well-documented harmful effects on non-target species. During application, the active ingredient glyphosate is utilized in various formulations, each containing different additive adjuvants.
View Article and Find Full Text PDFAurora A Kinase Begins to Localize to the Centrosome in the S-phase of the Cell Cycle in the XL2 Cell Line.
Front Biosci (Landmark Ed)
September 2024
Mixed Research Unit 6290, National Center for Scientific Research (CNRS), Institute of Genetics and Development of Rennes, University of Rennes 1, 35043 Rennes, France.
Background: The centrosome is one of the principal cell hubs, where numerous proteins important for intracellular regulatory processes are concentrated. One of them, serine-threonine kinase 6, alias Aurora A, is involved in centrosome duplication and mitotic spindle formation and maintenance.
Methods: Long-term vital observations of cells, immunofluorescence analysis of protein localization, synchronization of cells at different phases of the cell cycle, Western blot analysis of protein content were used in the work.
Mechanosensitive recruitment of Vinculin maintains junction integrity and barrier function at epithelial tricellular junctions.
Curr Biol
October 2024
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
Apical cell-cell junctions, including adherens junctions and tight junctions, adhere epithelial cells to one another and regulate selective permeability at both bicellular junctions and tricellular junctions (TCJs). Although several specialized proteins are known to localize at TCJs, it remains unclear how actomyosin-mediated tension transmission at TCJs contributes to the maintenance of junction integrity and barrier function at these sites. Here, utilizing the embryonic epithelium of gastrula-stage Xenopus laevis embryos, we define a mechanism by which the mechanosensitive protein Vinculin helps anchor the actomyosin network at TCJs, thus maintaining TCJ integrity and barrier function.
View Article and Find Full Text PDFWnt-5a/Ca pathway modulates endogenous current and oocyte structure of Xenopus laevis.
Biochem Biophys Res Commun
December 2024
Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Escuela de Medicina, Universidad de Magallanes, Punta Arenas, Chile. Electronic address:
Article Synopsis
- - Wnt signaling is crucial for various cellular processes, and Xenopus laevis oocytes serve as an effective model to study these mechanisms, particularly for receptors like Frizzled 7 found in the CNS.
- - Using two-electrode voltage clamp recordings, researchers discovered that Wnt-5a affects the oocyte's membrane currents, resulting in changes to calcium-dependent currents, membrane depolarization, and alterations in potential and outward potassium currents.
- - Wnt-5a treatment improved oocyte viability and enhanced germinal vesicle breakdown compared to the control, indicating that Wnt-5a influences oocyte structure and signaling, contributing to a deeper understanding of the Wnt pathway's cellular effects.
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