In organ transplantation, preservation injury is an important factor which could influence short-term and long-term graft outcome. The renal medulla is particularly sensitive to oxidant stress and ischemia-reperfusion injury (IRI). Using an autotransplant pig kidney model, we investigated renal function and medullary damage determined between day 1 and week 2 after 24- or 48-h cold storage in different preservation solutions: University of Wisconsin solution (UW), Hopital Edouard Herriot solution (a high Na+ version of UW), ECPEG (high Na+ preservation solution with PEG) and ICPEG (a high K+ version of ECPEG) with or without trimetazidine (TMZ). TMZ improved renal preservation and increased renal function when added in each preservation solution (particularly HEH and ECPEG). Medullary damage led to the early appearance of trimethylamine-N-oxide (TMAO) followed by 1H-NMR in urine and plasma. TMZ and ECPEG is the most efficient association to reduce medullary damage. This study clarifies the role of colloid and polarity solution and the role of mitochondrial protection by TMZ.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbagen.2004.03.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8 T cells and alleviating thymus injury.
Front Immunol
January 2025
Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Background: Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge.
View Article and Find Full Text PDFUnderstanding the Causes of Keel Bone Damage and Its Effects on the Welfare of Laying Hens.
Animals (Basel)
December 2024
Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.
Keel bone damage (KBD) is a prominent concern within the realm of the egg-laying industry, exerting substantial impacts on the welfare and productivity of laying hens. This comprehensive review undertakes a detailed exploration of the diverse factors contributing to KBD, such as inadequate calcium sources in the medullary bone, genetic factors, nutritional deficiencies, and physical stressors. The consequences of KBD on production performance, stress and inflammation levels, and the physical and chemical properties of the keel are meticulously examined.
View Article and Find Full Text PDFEpileptic Seizures As the Sole Presentation of a Radiologically Isolated Syndrome: A Case Report and Review of the Literature.
Cureus
December 2024
Department of Neurology, Cheikh Khalifa International University Hospital, Faculty of Medicine, Mohamed VI University of Health Sciences (UM6SS), Casablanca, MAR.
Multiple sclerosis (MS) is the most prevalent long-term inflammatory condition affecting the central nervous system in adults. However, seizures are rarely described as the first presentation of MS or as a sole manifestation of radiologically isolated syndrome (RIS) or clinically isolated syndrome (CIS). The diagnosis of MS typically requires clinical evidence of neurological deficits and supportive radiological findings; however, RIS is characterized by incidental magnetic resonance imaging (MRI) findings suggestive of MS in the absence of clinical symptoms.
View Article and Find Full Text PDFAdaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.
Cell Mol Life Sci
December 2024
Univ Angers, INSERM, CNRS, MITOVASC, Équipe CARME, SFR ICAT, F-49000 Angers, France.
Chronic elevated blood pressure impinges on the functioning of multiple organs and therefore harms body homeostasis. Elucidating the protective mechanisms whereby the organism copes with sustained or repetitive blood pressure rises is therefore a topical challenge. Here we address this issue in the adrenal medulla, the master neuroendocrine tissue involved in the secretion of catecholamines, influential hormones in blood pressure regulation.
View Article and Find Full Text PDFVitamin C Ameliorates Potassium Dichromate-Induced Oxidative Stress and Mitochondrial Dysfunction via PGC-1α/Nrf-2/TFAM Pathway.
J Biochem Mol Toxicol
January 2025
Department of Anatomy, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Exposure to potassium dichromate (KCrO) is well known for its nephrotoxic effects on humans and animals. This study investigated the protective effects of vitamin C against KCrO-induced nephrotoxicity, focusing on its impact on altered carbohydrate metabolism, mitochondrial dysfunction, and associated molecular mechanisms in the cortical and medullary kidney segments. Male Wistar rats (n = 8) were divided into four groups: Group I received saline, Group II received a single 250 mg/kg body weight (bwt) intraperitoneal (i.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!