Background: Testicular tumors in general can be classified as seminoma, embryonal carcinoma, teratocarcinoma, choriocarcinoma, and mixed tumors. Nevertheless, other histological types may also be observed. In rare cases, primary or secondary neuroendocrine tumors derived from chromaffine cells can be observed in the testicle.
Case Report: A 51-year-old patient was hospitalized on account of a two-month-old painless tumescence of the right testicle. Radical orchiectomy revealed a solid, inhomogeneous intratesticular tumor 3 cm in diameter. Pathohistological findings and immunohistochemical staining with different neuroendocrine markers revealed a testicular carcinoid classified as pT1. The excretion of 5-hydroxyindole-acetic acid (5-HIAA) was within the normal range. No further carcinoid tumor site was found.
Conclusions: In case of a testicular carcinoid, exclusion of a primary carcinoid tumor site in other organs is mandatory.
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Front Oncol
December 2024
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, United States.
Introduction: Choroidal metastases from systemic malignancies are the most common intraocular malignancies in adults. External beam radiation (EBR) has historically been first-line therapy for metastatic tumors to the choroid. However, good responses have been described with newer targeted biologics.
View Article and Find Full Text PDFHistopathology
December 2024
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Background: Knowledge regarding adenocarcinoma of the rete testis (ACRT) is extremely limited due to its scarcity.
Methods And Results: This study enrolled 18 patients with ACRT from multiple institutions. Clinicopathological and immunohistochemical features were investigated, together with a comprehensive review of 95 previously reported cases.
Cureus
May 2024
Laboratory Department, Prince Sultan Military Medical City, Riyadh, SAU.
Well-differentiated neuroendocrine tumors of the testis are exceedingly rare. Here, we report the case of a 47-year-old male patient complaining of cardiac symptoms with a right testicular mass. A right radical orchiectomy was performed.
View Article and Find Full Text PDFInt J Mol Sci
March 2024
Microscopy Core Facility, Biomedical Research Institute, Universidad Nacional Autónoma de México, Tercer Circuito Exterior S/N, Ciudad Universitaria, Mexico City 04510, Mexico.
Cryptorchidism (CO) or undescended testes is defined as the failure of one or both testes to be positioned inside the scrotum. Typically, cryptorchidism is detected at birth or shortly thereafter, and in humans, it is considered to be part of the testicular dysgenesis syndrome (TDS), a complex pathology regarding the male reproductive system that apparently involves the interaction of both genetic and environmental harmful factors, mainly during embryonic development. Serotonin (5-HT) is an ancient molecule that participates in a broad range of body functions, and in recent years, its importance in reproduction has started to be elucidated.
View Article and Find Full Text PDFClin Case Rep
March 2024
Department of Pathology, Firoozgar Hospital, School of Medicine Iran University of Medical Sciences Tehran Iran.
Key Clinical Message: A 32-year-old male with painful scrotal swelling who underwent radical orchiectomy and was diagnosed with a testicular neuroendocrine tumor. Determining whether testicular neuroendocrine tumor is primary or metastasis from another origin is crucial.
Abstract: Testicular neuroendocrine tumors (TNET) are one of the rarest human neoplasms, with about 132 identified cases until 2015.
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