AI Article Synopsis
- * Experimenting with mice, researchers found that injecting them with CpG oligonucleotides reduced TLR9 and led to fewer secretory granules in Paneth cells, indicating degranulation.
- * The treatment with CpG oligonucleotides also improved the mice's resistance to infection by Salmonella typhimurium, highlighting the protective function of Paneth cells through TLR9.
Article Abstract
The release of antimicrobial peptides and growth factors by Paneth cells is thought to play an important role in protecting the small intestine, but the mechanisms involved have remained obscure. Immunohistochemistry and immunofluorescence showed that Paneth cells express Toll-like receptor 9 (TLR9) in the granules. Injection of mice with oligonucleotides containing CpG sequence (CpG-ODNs) led to a down-modulation of TLR9 and a striking decrease in the number of large secretory granules, consistent with degranulation. Moreover CpG-ODN treatment increased resistance to oral challenge with virulent Salmonella typhimurium. Moreover, our findings demonstrate a sentinel role for Paneth cells through TLR9.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618569 | PMC |
| http://dx.doi.org/10.1016/S0002-9440(10)63304-4 | DOI Listing |
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