We carried out a retrospective immunohistochemical study of Ki-67, PCNA, Bcl-2, BAX, BclX, and VEGF expression in tumors of two groups of breast cancer patients with favorable and unfavorable course of the disease. Considerably enhanced VEGF expression was detected in tumors of patients with early relapses of breast cancer. High VEGF expression was paralleled by high level of Ki-67 and PCNA expression in tumors. It can be hypothesized that expression of VEGF, Ki-67, and PCNA in primary tumor can be used for predicting the course of breast cancer or detecting the patients at a high risk of early relapses.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1023/b:bebm.0000028135.91289.e9 | DOI Listing |
Publication Analysis
Top Keywords
ki-67 pcna
16
vegf expression
12
breast cancer
12
pcna bcl-2
8
bcl-2 bax
8
bax bclx
8
bclx vegf
8
expression tumors
8
early relapses
8
expression
6
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!