High-level resistance to ertapenem was produced by beta-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 microg/ml and expression of outer membrane proteins was diminished could be selected.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC478483 | PMC |
| http://dx.doi.org/10.1128/AAC.48.8.3203-3206.2004 | DOI Listing |
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