In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC478552 | PMC |
| http://dx.doi.org/10.1128/AAC.48.8.3122-3126.2004 | DOI Listing |
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