AI Article Synopsis
- N19 is a combination of human CD4 T-cell epitopes that is more effective than CRM197 for boosting immune response against Neisseria meningitidis capsular polysaccharide (MenC) in mice.
- After two doses, N19-induced antibodies that were more robust than those produced by three doses of CRM, showing a higher level of protective immunity.
- The study suggests that N19 conjugates require smaller amounts for effective immunization compared to CRM-based conjugates, marking them as a better option for inducing protective immune responses.
Article Abstract
N19, a string of human universal CD4 T-cell epitopes from various pathogen-derived antigens, was shown to exert a stronger carrier effect than CRM197 for the induction of anti-group C Neisseria meningitidis capsular polysaccharide (MenC), after immunization of mice with various dosages of N19-MenC or CRM-MenC conjugate vaccines. After two immunizations, the N19-based construct induced anti-MenC antibody and protective bactericidal antibody titers higher than those induced by three doses of the CRM-MenC conjugate and required lower amounts of conjugate. N19-based conjugates are superior to CRM-based conjugates to induce protective immune responses to MenC conjugates.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470654 | PMC |
| http://dx.doi.org/10.1128/IAI.72.8.4884-4887.2004 | DOI Listing |
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