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Effect of pH on the production of the antitumor antibiotic retamycin by Streptomyces olindensis. | LitMetric
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Effect of pH on the production of the antitumor antibiotic retamycin by Streptomyces olindensis.

Luciana M Guimarães Renata L de Araújo Furlan Leandro M Garrido Armando Ventura Gabriel Padilla Maria Cândida R Facciotti

Biotechnol Appl Biochem

Departamento de Engenharia Química, Escola Politécnica da Universidade de São Paulo, P.O. Box 61548, CEP 05424-970, São Paulo, SP, Brazil.

Published: August 2004

The effect of pH on cell growth and retamycin production in batch bioreactor cultures of Streptomyces olindensis ICB20 was investigated. In fermentations pH-controlled over the range 6.0-8.0, the highest retamycin production was achieved at pH 7.0, and the maximum concentration of retamycin, about 1.36 A (absorbance) units, was about 43, 58 and 232% higher than the values obtained at pH 7.5, 6.0 and 8.0 respectively.

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http://dx.doi.org/10.1042/BA20030166DOI Listing

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