Purpose: To observe the clinical effect of using the domestic BME-10X medical collagen membrane and hydroxyapatite (HA) in guide tissue regeneration of the bone defects caused by periodontitis and periapical cyst.

Methods: 18 cases with 9 points in 9 teeth with II degree furation involvement, 16 points in 11 teeth with 2 or 3 bone bottom pockets and 6 cases with periapical cyst were chosen in our study. The defect region of alveolar bone was stuffed with HA and covered with collagen membrane. The pathological changes after over one year were observed and recorded.

Results: The pathological changes of alveolar bone defects were significant in 7 cases with furcation involvements (77.8%),12 cases with bone bottom pockets (75%),and 6 cases of periapical cyst (100%).

Conclusion: The combination of collagen membrane and HA can be applied in repairing the alveolar bone defects resulting form periodontitis and periapical cysts.

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