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The current clinical approach to feeding and eating disorders aimed to increase personalization of management.
World Psychiatry
February 2025
School of Health in Social Science, University of Edinburgh, Edinburgh, UK.
Feeding and eating disorders (FEDs) are a heterogeneous grouping of disorders at the mind-body interface, with typical onset from childhood into emerging adulthood. They occur along a spectrum of disordered eating and compensatory weight management behaviors, and from low to high body weight. Psychiatric comorbidities are the norm.
View Article and Find Full Text PDFChildhood obesity poses a significant public health challenge, yet the molecular intricacies underlying its pathobiology remain elusive. Leveraging extensive multi-omics profiling (methylome, miRNome, transcriptome, proteins and metabolites) and a rich phenotypic characterization across two parts of Europe within the population-based Human Early Life Exposome project, we unravel the molecular landscape of childhood obesity and associated metabolic dysfunction. Our integrative analysis uncovers three clusters of children defined by specific multi-omics profiles, one of which characterized not only by higher adiposity but also by a high degree of metabolic complications.
View Article and Find Full Text PDFPrimary breast Burkitt lymphoma with lactic acidosis in a child: a case report.
Turk J Pediatr
December 2024
Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Background: Primary breast lymphoma is extremely rare and constitutes approximately 1% of all non-Hodgkin's lymphomas (NHL). Only 1-5% of them are Burkitt type. We present a case of childhood primary breast Burkitt lymphoma (BL).
View Article and Find Full Text PDFKlinefelter Syndrome: A Review.
Clin Endocrinol (Oxf)
January 2025
Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool, UK.
Background: Klinefelter syndrome (KS) is an uncommonly recognised condition typified by gynaecomastia, small testes and aspermatogenesis. It is caused by a supernumerary X chromosome, resulting in a 47 XXY karyotype. Since its first description, the phenotype of KS has evolved and there is a much greater appreciation of the subtle features of the condition.
View Article and Find Full Text PDFAssociation between obesity and thyroid nodules in children and adults living in iodine-sufficient areas: analysis of cross-sectional data from Tianjin, China.
BMJ Open
December 2024
Tianjin Centers for Disease Control and Prevention, Tianjin, Hedong District, China
Objective: The main purpose of this study was to analyse the association between obesity and thyroid nodules in children and adults living in iodine-sufficient areas in China.
Design: Analysis of data from two cross-sectional surveys.
Setting And Participants: 921 children from 2016 to 2021 and 1505 adults from 2018 to 2021 living in iodine-sufficient areas from Tianjin, China were recruited.
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