Various stabilizers containing no animal-derived components were assessed for their efficacy in stabilizing live attenuated varicella virus under various storage temperatures. Stabilizers containing carrageenan, soy protein hydrolysates, or sucrose had a satisfactory performance to maintain infectivity of the cell-free virus when compared to control stabilizer containing animal-derived gelatin/gelatin hydrolysate.
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http://dx.doi.org/10.1023/b:bile.0000025883.04938.4e | DOI Listing |
Hereditas
January 2025
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 182 Chunhui Road, Longmatan District, Luzhou, Sichuan, 646000, China.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, with antibody-mediated immune responses to infectious diseases agents potentially playing a decisive role in its pathophysiological process. However, the causal relationship between antibodies and AD remains unclear.
Methods: A two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal link between antibody-mediated immune responses to infectious diseases agents and the risk of AD.
Alzheimers Dement
December 2024
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
Background: Early Onset Alzheimer's Disease (EOAD) is thought to result from a combination of environmental, genetic, and lifestyle factors. Herpesvirus infections may contribute to the development of EOAD and the objective of our study is to identify potential associations between herpes virus infections and the risk of developing EOAD.
Method: Amyloid-status Alzheimer's disease was diagnosed based on clinical history and ATN criteria, determined by the measuring the Amyloidß42:40 ratio, tau, and 181-Phospho-tau in the cerebrospinal fluid.
Acta Derm Venereol
January 2025
Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel; Pediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, Israel.
This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls.
View Article and Find Full Text PDFInt J Emerg Med
January 2025
Emergency Department, Taipei Veterans General Hospital, Taipei, 112, Taiwan.
Background: Ramsay Hunt syndrome (RHS), a rare complication of varicella-zoster virus (VZV) reactivation, presents with ipsilateral facial paralysis, ear pain, and vesicular rash. Early recognition is crucial for prompt treatment and optimal outcomes.
Case Presentation: We report a case of a 67-year-old woman with RHS who presented with right-sided facial palsy, severe ear pain, and fluid-filled blisters.
Inn Med (Heidelb)
January 2025
Medizinischen Klinik I, Agaplesion Markus Krankenhaus, Wilhelm-Epstein-Str. 4, 60431, Frankfurt/Main, Deutschland.
Background: The treatment options for chronic inflammatory bowel diseases (IBD) have been greatly expanded due to a better understanding of the underlying pathogenesis. A total of five classes of advanced treatment are available.
Objective: A practical overview of advanced treatment of IBD.
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