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Purpose: To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing's disease.
Methods: Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), both comprising a 48-week core phase and an optional open-label extension. Changes from baseline in systolic and diastolic BP (SBP and DBP), fasting plasma glucose (FPG), and glycated hemoglobin (HbA) were evaluated during osilodrostat treatment in patients with/without hypertension or diabetes at baseline.
Assessing learning, behaviour, and stress level in goats while testing a virtual fencing training protocol.
Animal
December 2024
Venn Research Association for the Promotion of Virtual Fencing in Tyrol and the Alpine region. Brixnerstraße 1, 6020 Innsbruck, Austria.
Virtual fencing (VF) is a modern fencing technology using Global Positioning System-enabled collars which emit acoustic signals and, if the animal does not respond, electric pulses. Studies with cattle indicate successful learning and no distinct negative impact on the animals' behaviours and stress level. However, the number of studies testing VF with goats is relatively small.
View Article and Find Full Text PDFEffects of a Footbathing Intervention on Physiological, Endocrine, and Psychological Status in Japanese University Students: A Randomized Controlled Trial.
Int J Environ Res Public Health
December 2024
Faculty of Letters, Arts and Sciences, Waseda University, Tokyo 162-8644, Japan.
The present pilot study examined effectiveness of a 2-week footbathing intervention on physiological, endocrine, and psychological status in healthy Japanese university students. A total of 51 participants were randomly assigned to a footbathing or normal bathing group. Participants in both groups provided daily free descriptions of their physical and mental states during the intervention period.
View Article and Find Full Text PDFPersistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study.
PLoS Med
January 2025
Division of Infectious Diseases, Department of Medicine II, Medical Centre and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Background: Self-reported health problems following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are common and often include relatively non-specific complaints such as fatigue, exertional dyspnoea, concentration or memory disturbance and sleep problems. The long-term prognosis of such post-acute sequelae of COVID-19/post-COVID-19 syndrome (PCS) is unknown, and data finding and correlating organ dysfunction and pathology with self-reported symptoms in patients with non-recovery from PCS is scarce. We wanted to describe clinical characteristics and diagnostic findings among patients with PCS persisting for >1 year and assessed risk factors for PCS persistence versus improvement.
View Article and Find Full Text PDFPotassium-Rich, Gluten-Free Diets for Patients with Sjögren's Syndrome: A Hypothesis.
Endocr Metab Immune Disord Drug Targets
January 2025
Department of Clinical and Experimental Medicine, Gastroenterology Section, "Gaspare Rodolico" Policlinico Hospital, University of Catania, Catania, Italy.
Sjögren's syndrome (SS) is an autoimmune disease and its management is palliative. There is no specific dietary protocol for SS patients. A gluten-free diet has been tested in SS patients with celiac disease (CD) and indicated modest improvements.
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