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Necrotizing fasciitis (NF) is a rare but rapidly progressive and potentially fatal disease condition. It is characterized by progressive inflammation and extensive necrosis of the subcutaneous tissue and fascia, sparing the underlying tissue. It is a poly-bacterial infection and is associated with profound systemic toxicity, considerable morbidity and a high mortality rate. The outcome is influenced by early recognition and radical surgical debridement. We present a report of six cases of NF who presented to our surgical service within the past 5 years.
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http://dx.doi.org/10.1177/004947550403400320 | DOI Listing |
Aim: Skin and soft tissue infection (SSTI) is classified as necrotizing fasciitis (NF) or cellulitis based on the invasion depth of the lesion. Cellulitis has a good prognosis and improves with conservative treatment, whereas NF has a poor prognosis with rapid progression requiring prompt debridement of the wound and intensive care control. Therefore, they should be differentiated quickly and accurately; however, a useful diagnostic method, except for the surgical test incision, remains to be established.
View Article and Find Full Text PDFInt J Emerg Med
March 2025
Department of Emergency Medicine, Arrowhead Regional Medical Center, 400 N. Pepper Ave, Colton, CA, 92324, USA.
Introduction: Necrotizing Fasciitis (NF) is a rare life-threatening bacterial infection that necessitates emergent resuscitation and operative intervention. Most of the literature has emphasized the need for early surgical intervention. This is problematic for patients being treated at a facility lacking surgical support, with concerns for increasing mortality and morbidity rates.
View Article and Find Full Text PDFPediatr Infect Dis J
March 2025
From the Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Background: An unprecedented increase in pediatric invasive group A streptococcal (iGAS) infections was observed in most countries, including Iceland, in early 2023. The reasons for this rise are largely unknown. The aim of the study was to describe the parallel between nasopharyngeal (NP) carriage of group A streptococcal (GAS) in Icelandic children and the incidence of invasive disease.
View Article and Find Full Text PDFCureus
February 2025
Cardiovascular and Thoracic Surgery, RUSH University Medical Center, Chicago, USA.
Pulmonary mucormycosis (PM) is a severe fungal infection that predominantly affects immunocompromised and diabetic individuals, and it is associated with a high mortality rate, particularly in cases of disseminated disease. We present the case of a 29-year-old liver transplant recipient who developed aggressive PM, confirmed through bronchoalveolar lavage. Treatment involved liposomal amphotericin B, followed by surgical debridement and right pneumonectomy.
View Article and Find Full Text PDFNecrotizing fasciitis (NF) is an infection of the deep soft tissues that results in progressive destruction of the muscle fascia and overlying subcutaneous fat. These infections can be sudden, vicious, and fast-spreading. If not treated quickly with antibiotics and debridement of the infected tissue, the patient may develop septic shock, which may lead to multiple organ failure and death.
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