Paraneoplastic syndromes associated with prostate carcinoma are very rare. We report a patient with prostate carcinoma and cholestatic jaundice without biliary obstruction, hepatic involvement or infectious etiology. In the literature, only one case of idiopathic cholestatic jaundice with prostate carcinoma has been reported and a paraneoplastic etiology was suggested. In our case, cholestasis rapidly regressed with chemotherapy and the patient is well at six months of follow-up. Paraneoplastic cholestasis should be kept in mind in the absence of biliary tract obstruction, hepatic involvement or infectious etiology.
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