Study Objective: To determine whether nitroglycerin or trimethaphan alters pressor response to intravenous (i.v.) ephedrine.
Design: Prospective, randomized study.
Setting: Operating room of a university hospital.
Patients: 60 ASA physical status I female patients scheduled for mastectomy.
Interventions: Patients were assigned to one of six groups (n = 10 in each). Group 1: nitroglycerin + normal saline (NS) i.v., Group 2: nitroglycerin + ephedrine 0.1 mg/kg i.v., Group 3: nitroglycerin + ephedrine 0.15 mg/kg i.v., Group 4: trimethaphan + NS i.v., Group 5: trimethaphan + ephedrine 0.1 mg/kg i.v., and Group 6: trimethaphan + ephedrine 0.15 mg/kg i.v.
Measurements: Hemodynamic responses to ephedrine following withdrawal of vasodilators were observed for 15 minutes.
Main Results: Ephedrine increased heart rate and mean blood pressure. After ephedrine 0.1 mg/kg i.v., the maximum pressor response in the trimethaphan group was approximately twofold that of the nitroglycerin group (p = 0.038).
Conclusions: Ephedrine restored BP more easily in those patients who had received trimethaphan compared with those who had received nitroglycerin for deliberate hypotension.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jclinane.2003.09.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical Correlates of Efficacy of Pyridostigmine in the Treatment of Orthostatic Hypotension.
Hypertension
December 2024
Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN. (L.E.O., A.D., C.A.S., A.G., B.K.B., S.P., I.B.).
Background: The cholinesterase inhibitor pyridostigmine is used to treat orthostatic hypotension by facilitating cholinergic neurotransmission in autonomic ganglia, thereby harnessing residual sympathetic tone to increase blood pressure (BP) preferentially in the upright posture. We hypothesized that less severe autonomic impairment was associated with greater pressor responses to pyridostigmine.
Methods: To identify predictors of pressor response, linear regression analyses between the effect of pyridostigmine on upright BP and markers of autonomic impairment were retrospectively conducted on 38 patients who had a medication trial with pyridostigmine (60 mg single dose).
Long-term egg-protein hydrolysate consumption improves endothelial function: a randomized, double-blind, placebo-controlled trial in older adults with overweight or obesity.
Eur J Nutr
December 2024
Department of Nutrition and Movement Sciences, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Purpose: The dietary egg-protein hydrolysate Newtricious (NWT)-03 has previously demonstrated improvements in blood pressure and metabolic profiles. However, the long-term effects on vascular function and cardiometabolic risk markers are unknown.
Methods: Forty-four older (aged 60-75) adults with overweight/obesity experiencing elevated Subjective Cognitive Failures (SCF) were randomized into a 36-week, double-blind, placebo-controlled trial.
Photoplethysmography as a noninvasive surrogate for microneurography in measuring stress-induced sympathetic nervous activation - A machine learning approach.
Comput Biol Med
December 2024
School of Information Technology, Deakin University, Melbourne, Victoria, Australia. Electronic address:
The sympathetic nervous system (SNS) is essential for the body's immediate response to stress, initiating physiological changes that can be measured through sympathetic nerve activity (SNA). While microneurography (MNG) is the gold standard for direct SNA measurement, its invasive nature limits its practical use in clinical settings. This study investigates the use of multi-wavelength photoplethysmography (PPG) as a non-invasive alternative for SNA measurement.
View Article and Find Full Text PDFPolycystic ovary syndrome potentiates blood pressure and vascular responses to the cold pressor test.
J Appl Physiol (1985)
December 2024
Cardiovascular Health and Autonomic Regulation Laboratory, Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada.
Polycystic ovary syndrome (PCOS) predisposes women to cardiovascular diseases. Blood pressure (BP) responses to the cold pressor test (CPT) predict future cardiovascular risk but have yet to be characterized in PCOS. Therefore, we compared BP responses to the CPT between females with PCOS (n=10; age: 22±3yr, body mass index (BMI): 23.
View Article and Find Full Text PDFImpact of provoked stress on model-free and model-based reinforcement learning in individuals with alcohol use disorder.
Addict Behav Rep
December 2024
Laboratoire de Psychologie Médicale et d'Addictologie, Université Libre de Bruxelles (ULB), place Van Gehuchten 4, 1020 Brussels, Belgium.
Background: From both clinical and theoretical perspectives, understanding the functionality of evaluative reinforcement learning mechanisms (Model-Free, MF, and Model-Based, MB) under provoked stress, particularly in Alcohol Use Disorder (AUD), is crucial yet underexplored. This study aims to evaluate whether individuals with AUD who do not seek treatment show a greater tendency towards retrospective behaviors (MF) rather than prospective and deliberative simulations (MB) compared to controls. Additionally, it examines the impact of induced social stress on these decision-making processes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!