The optimization of a series of nonsteroidal glucocorticoid modulators is reported. Potent selective GR ligands that have improved metabolic stability were discovered typified by the subnanomolar acid 12 (GR binding IC(50)=0.6 nM).
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| http://dx.doi.org/10.1016/j.bmcl.2004.06.023 | DOI Listing |
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