Hemorheological parameters were investigated before, during, and after the standard burn of the distal part of the rabbits' ear shell (54 degrees C for 3 minutes). The erythrocyte aggregation was investigated with the "Georgian technique" and the local hematocrit was determined by centrifugation of blood samples from the inflammatory focus. In addition, we determined the size of the inflammatory edema in the ear shell. We found that the erythrocyte aggregability rised by 3.7 times in the venous blood flowing out from the inflammation focus while the hematocrit increased 1.6 times as compared to the microcirculation in the contralateral (control) ear shall. The thickness of this latter related to edema development increased three times. All the mentioned changes disappeared within five days after start of the experiments. We concluded that in the aseptic inflammatory foci the erythrocyte aggregability increases considerably in the microcirculation producing capillary stases and enhancing the local hematocrit. The hemorheological disorders were not spread to other parts of the circulatory bed.
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Rev Bras Parasitol Vet
January 2025
Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Medicina Veterinária - FAVET, Universidade Federal de Mato Grosso - UFMT Cuiabá, MT, Brasil.
Canine monocytic ehrlichiosis (CME) is an infectious disease that causes hematological changes in dogs. This study investigated the correlations between hematological and hemorheological parameters, serum proteins, and triglycerides in dogs with CME. Fifty-nine blood and/or bone marrow samples were collected from dogs with or without clinical signs of CME.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Department of Laboratory Medicine, Liuzhou Key Laboratory of Precision Medicine for Viral Diseases, Guangxi Health Commission Key Laboratory of Clinical Biotechnology (Liuzhou People's Hospital), Liuzhou People's Hospital, Liuzhou 545006, China.
J Ethnopharmacol
February 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, 310053, China. Electronic address:
Ethnopharmacological Relevance: Unhealthy dietary patterns and lifestyle changes have been linked to increased blood viscosity, which is recognized as an important pathogenic factor in cardiovascular and cerebrovascular diseases. The underlying mechanism may involve chronic inflammation resulting from intestinal barrier disruption induced by unhealthy diets. The rhizome of Atractylodes macrocephala Koidz.
View Article and Find Full Text PDFInt J Lab Hematol
February 2025
Department of Biophysics, University of Health Sciences, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Background: The aim of this study is to determine whether there are any changes in hemorheological parameters, including whole blood viscosity (WBV), plasma viscosity, erythrocyte aggregation, and erythrocyte deformability, in acute ischemic stroke patients, and to establish their relationship with stroke etiology. The study also aims to observe the changes in these parameters, if any, over time and after treatment, and to assess the correlation between risk factors for ischemic stroke and neuroimaging findings.
Methods: This was a prospective observational study including 70 patients diagnosed with acute ischemic stroke within the first 3 days of the onset of symptoms and 96 healthy controls.
Comput Methods Programs Biomed
December 2024
Department of Mechanical Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand 826004, India. Electronic address:
Background And Objective: Stenosis or narrowing of arteries due to the buildup of plaque is a common occurrence in atherosclerosis and coronary artery disease (CAD), limiting blood flow to the heart and posing substantial cardiovascular risk. While the role of geometric irregularities in arterial stenosis is well-documented, the complex interplay between the abnormal hemorheology and asymmetric shape in flow characteristics remains unexplored.
Methods: This study investigates the influence of varying hematocrit (Hct) levels, often caused by conditions such as diabetes and anemia, on flow patterns in an idealized eccentric stenotic artery using computational fluid dynamics simulations.
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