AI Article Synopsis
- The study aimed to assess the impact of hyperfractionated radiation therapy combined with chemotherapy on inoperable stage III non-small cell lung cancer (NSCLC).
- Seventy patients were divided into two groups: one received the combined treatment while the other only received chemotherapy.
- Results showed a higher overall response rate in the combined treatment group (60%) compared to the chemotherapy-only group (40%), but survival rates did not significantly improve despite better short-term responses.
Article Abstract
Objective: To evaluate the effect of hyperfractionated radiation therapy and concomitant chemotherapy for inoperable stage III non-small cell lung cancer (NSCLC).
Methods: Seventy patients were randomized equally into two group. The therapy group received radiotherapy with hyperfractionated radiation therapy combined with concomitant chemotherapy, and the control group was treated with chemotherapy only.
Result: The overall response rate, including the rate of both complete (CR) and partial responses (PR), in the therapy group was 60.0% with a CR rate of 8.6%. The overall response rate in the control group was 40.0% with a CR rate of 5.7%. The difference in overall response rate was statistically significant between the two groups (P<0.05). The median survival time, 1- and 2-years survival rate were 12.8 months, 48.6%, and 25.7%, respectively, in the hyperfractionated radiotherapy group, and 9.4 months, 34.3%, and 17.1%, respectively, in the chemotherapeutic group (P 0.031). The major toxic effects of the chemotherapy were myelosuppression and radiation esophagitis.
Conclusion: Hyperfractionated radiation therapy plus concomitant chemotherapy with paclitaxel for inoperable stage III NSCLC improves the short-term response of the patients, but fail to raise the survival rate.
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